Anaam Al-Qudah 

Email: alqudahanaam7@gmail.com

Location: Irbid, Jordan

Thesis Title: Synthesis and Characterization of Nickel-Doped Zinc Oxide Nanoparticles for Anticancer Potential

Thesis Description:

My research focuses on synthesizing and characterizing zinc oxide nanoparticles (ZnONPs) and nickel-doped ZnO nanoparticles (Ni/ZnONPs) to explore their potential anticancer activity. Structural characterization using XRD and SEM showed that the incorporation of Ni ions increases both crystallite size and microstrain. FTIR and XRF analyses further confirmed successful doping of ZnO with Ni.

Electrical measurements revealed a significant enhancement in conductivity—from 0.31 to 1.61 S·cm⁻¹—alongside a notable reduction in bandgap energy from 3.27 to 2.49 eV as the Ni concentration increased to 20 wt.%. Biological evaluations using the MTT assay demonstrated that Ni/ZnONPs, particularly those with 20 wt.% Ni, exhibited strong cytotoxicity against MCF-7 breast cancer cells, with cell viability dropping to 26% at 512 μg·mL⁻¹. This enhanced performance is attributed to increased ROS generation and improved cellular uptake.

These findings contribute valuable insights to the field of nanomaterials for cancer therapy and highlight the importance of collaboration between graduate students and academic researchers.

Status:

She graduated and is currently working as a Research Assistant.